Wang, Yuan and Li, Jiajia and Li, Jingjing and Li, Peipei and Wang, Li and Di, Lijun (2020) An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion. Frontiers in Genetics, 11. ISSN 1664-8021
pubmed-zip/versions/1/package-entries/fgene-11-595550/fgene-11-595550.pdf - Published Version
Download (10MB)
Abstract
Cancer is characterized by dysregulation at multiple levels, such as gene transcription. Enhancers are well-studied transcription regulators that can enhance target transcripts through DNA loop formation mediated by chromosome folding. The gain or loss of the interaction between an enhancer and its target gene has a critical effect on gene expression. In this study, we analyzed GRO-seq data to identify active enhancers from seven common cancer cell lines and studied the function of these enhancers across multiple cancer types. By constructing an “enhancer effect score” (EES), we found a significant correlation between EES and tumor-infiltrating lymphocytes (TILs) in prostate cancer. Further analysis revealed that androgen receptor (AR) plays an important role in regulating the immune checkpoint gene PVR via its enhancer. These results suggest that AR contributes to prostate cancer aggressiveness by promoting cancer cell immune evasion.
Item Type: | Article |
---|---|
Subjects: | South Asian Library > Medical Science |
Depositing User: | Unnamed user with email support@southasianlibrary.com |
Date Deposited: | 31 Jan 2023 11:03 |
Last Modified: | 17 Jun 2024 07:02 |
URI: | http://journal.repositoryarticle.com/id/eprint/142 |