Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development

Xu, Congyu and Yu, Linjie and Hou, Jinxing and Jackson, Rosemary J. and Wang, He and Huang, Chaoli and Liu, Tingting and Wang, Qihui and Zou, Xiaochuan and Morris, Richard G. and Spires-Jones, Tara L. and Yang, Zhongzhou and Yin, Zhenyu and Xu, Yun and Chen, Guiquan (2017) Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102

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Official URL: https://doi.org/10.3389/fncel.2017.00330

Abstract

Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study in vivo function of PDK1 in neuron survival during cortical development, we generate forebrain-specific PDK1 conditional knockout (cKO) mice. We demonstrate that PDK1 cKO mice display striking neuron loss and increased apoptosis. We report that PDK1 cKO mice exhibit deficits on several behavioral tasks. Moreover, PDK1 cKO mice show decreased activities for Akt and mTOR. These results highlight an essential role of endogenous PDK1 in the maintenance of neuronal survival during cortical development.

Item Type:	Article
Subjects:	South Asian Library > Physics and Astronomy
Depositing User:	Unnamed user with email support@southasianlibrary.com
Date Deposited:	05 Jun 2023 05:33
Last Modified:	13 Sep 2024 07:45
URI:	http://journal.repositoryarticle.com/id/eprint/1004

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